Existence of Quantum Pharmacology in Sartans: Evidence in Isolated Rabbit Iliac Arteries.

ABSTRACT: Quantum pharmacology introduces theoretical models to describe the possibility of ultra-high dilutions to produce biological effects, which may help to explain the placebo effect observed in hypertensive clinical trials. To determine this within physiology and to evaluate novel ARBs, we tested the ability of known angiotensin II receptor blockers (ARBs) (candesartan and telmisartan) used to treat hypertension and other cardiovascular diseases, as well as novel ARBs (benzimidazole-N-biphenyl tetrazole (ACC519T), benzimidazole-bis-N,N'-biphenyl tetrazole (ACC519T(2)) and 4-butyl-N,N0-bis[[20-2Htetrazol-5-yl)biphenyl-4-yl]methyl)imidazolium bromide (BV6(K⁺)₂), and nirmatrelvir (the active ingredient in Paxlovid) to modulate vascular contractio

SUBMITTER: Gadanec LK 

PROVIDER: S-EPMC10744031 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature