Oral Antibiotics for Bacteremia and Infective Endocarditis: Current Evidence and Future Perspectives.

ABSTRACT: Bacteremia and endocarditis are two clinical syndromes that, for decades, were managed exclusively with parenteral antimicrobials, irrespective of a given patient's clinical condition, causative pathogen, or its antibiotic susceptibility profile. This clinical approach, however, was based on low-quality data and outdated expert opinions. When a patient's condition has improved, gastrointestinal absorption is not compromised, and an oral antibiotic regimen reaching adequate serum concentrations is available, a switch to oral antibacterials can be applied. Although available evidence has reduced the timing of the oral switch in bacteremia to three days/until clinical improvement, there are only scarce data regarding less than 10-day intravenous antibiotic therapy in endocarditis. Many standa

SUBMITTER: Eleftheriotis G 

PROVIDER: S-EPMC10745436 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature