Ontology highlight
ABSTRACT:
SUBMITTER: Yamaguchi H
PROVIDER: S-EPMC10750295 | biostudies-literature | 2024
REPOSITORIES: biostudies-literature
Yamaguchi Hirohito H Chang Ling-Chu LC Chang Olin Shih-Shin OS Chen Yu-Fu YF Hsiao Yu-Chun YC Wu Chen-Shiou CS Hung Mien-Chie MC
International journal of biological sciences 20240101 1
To find new molecular targets for triple negative breast cancer (TNBC), we analyzed a large-scale drug screening dataset based on breast cancer subtypes. We discovered that BDP-9066, a specific MRCK inhibitor (MRCKi), may be an effective drug against TNBC. After confirming the efficacy and specificity of BDP-9066 against TNBC <i>in vitro</i> and <i>in vivo</i>, we further analyzed the underlying mechanism of specific activity of BDP-9066 against TNBC. Comparing the transcriptome of BDP-9066-sens ...[more]