PGF_2α induces a pro-labour phenotypical switch in human myometrial cells that can be inhibited with PGF_2α receptor antagonists.

ABSTRACT: Preterm birth is the leading cause of infant morbidity and mortality. There has been an interest in developing prostaglandin F_2α (PGF_2α) antagonists as a new treatment for preterm birth, although much of the rationale for their use is based on studies in rodents where PGF_2α initiates labour by regressing the corpus luteum and reducing systemic progesterone concentrations. How PGF_2α antagonism would act in humans who do not have a fall in systemic progesterone remains unclear. One possibility, in addition to an acute stimulation of contractions, is a direct alteration of the myometrial smooth muscle cell state towards a pro-labour phenotype. In this study, we developed an immortalised myometrial cell line, MYLA, derived from myometrial tissue obta

SUBMITTER: Hamshaw I 

PROVIDER: S-EPMC10752971 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature