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CIZ1 in Xist seeded assemblies at the inactive X chromosome.

ABSTRACT: There is growing evidence that X-chromosome inactivation is driven by phase-separated supramolecular assemblies. However, among the many proteins recruited to the inactive X chromosome by Xist long non-coding RNA, so far only a minority (CIZ1, CELF1, SPEN, TDP-43, MATR3, PTBP1, PCGF5) have been shown to form Xist-seeded protein assemblies, and of these most have not been analyzed in detail. With focus on CIZ1, here we describe 1) the contribution of intrinsically disordered regions in RNA-dependent protein assembly formation at the inactive X chromosome, and 2) enrichment, distribution, and function of proteins within Xist-seeded assemblies.

SUBMITTER: Sofi S

PROVIDER: S-EPMC10753822 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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CIZ1 in Xist seeded assemblies at the inactive X chromosome.

Sofi Sajad S Coverley Dawn D

Frontiers in cell and developmental biology 20231213

There is growing evidence that X-chromosome inactivation is driven by phase-separated supramolecular assemblies. However, among the many proteins recruited to the inactive X chromosome by <i>Xist</i> long non-coding RNA, so far only a minority (CIZ1, CELF1, SPEN, TDP-43, MATR3, PTBP1, PCGF5) have been shown to form <i>Xist</i>-seeded protein assemblies, and of these most have not been analyzed in detail. With focus on CIZ1, here we describe 1) the contribution of intrinsically disordered regions ...[more]

PMID: 38155839

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2019-01-14 | GSE109395 | GEO

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