Association of cardiac biomarkers, kidney function, and mortality among adults with chronic kidney disease.

ABSTRACT:

Background and aims

The performance of high sensitivity troponin T (hs-cTnT), hs-cTnI, and N-terminal pro-hormone brain natriuretic peptide (NT-proBNP) in patients with chronic kidney disease (CKD) is poorly understood.

Methods

We included adults with CKD (eGFR<60 ml/min/1.73m²) in the 1999-2004 NHANES. We calculated the 99^th percentile of hs-cTnT, hs-cTnI (Abbott, Ortho, and Siemens assays), and NT-proBNP, measured the association between eGFR and cardiac biomarker concentration, and used Cox regression models to assess the relationship between cardiac biomarkers and CVD mortality.

Results

Across 1,068 adults with CKD, the mean [SD] age was 71.9[12.7] years and 61.2% were female; 78.8% had elevated NT-proBNP and 42.6% had elevated hs-cTnT based

SUBMITTER: Claudel SE 

PROVIDER: S-EPMC10760296 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature