Dataset Information

Association of cardiac biomarkers, kidney function, and mortality among adults with chronic kidney disease.

ABSTRACT:

Background and aims

The performance of high sensitivity troponin T (hs-cTnT), hs-cTnI, and N-terminal pro-hormone brain natriuretic peptide (NT-proBNP) in patients with chronic kidney disease (CKD) is poorly understood.

Methods

We included adults with CKD (eGFR<60 ml/min/1.73m²) in the 1999-2004 NHANES. We calculated the 99^th percentile of hs-cTnT, hs-cTnI (Abbott, Ortho, and Siemens assays), and NT-proBNP, measured the association between eGFR and cardiac biomarker concentration, and used Cox regression models to assess the relationship between cardiac biomarkers and CVD mortality.

Results

Across 1,068 adults with CKD, the mean [SD] age was 71.9[12.7] years and 61.2% were female; 78.8% had elevated NT-proBNP and 42.6% had elevated hs-cTnT based on traditional clinical reference limits. The 99^th percentile of hs-cTnT was 122 ng/L (95% confidence interval (CI) 101-143), hs-cTnI_Abbott was 69 ng/L (95% CI 38-99), and NT-proBNP was 8952 pg/mL (95% CI 7506-10,399). A 10 ml/min decrease in eGFR was associated with greater increases in hs-cTnT and NT-proBNP than hs-cTnI (hs-cTnT: 27.5% increase (β=27.5, 95% CI 28.2-43.3)), NT-proBNP 46.0% increase (β=46.0, 95% CI 36.0-56.8), hs-cTnI_Siemens 17.9% (β=17.9, 95% CI 9.7-26.7). Each doubling of hs-cTnT, hs-cTnI, and NT-proBNP were associated with CVD mortality (hs-cTnT HR 1.62 [95% CI 1.32-1.98], p<0.0001; hs-cTnI_Siemens HR 1.40 [95% CI 1.26-1.55], p<0.0001; NT-proBNP HR 1.29 [95% CI 1.19-1.41], p<0.0001).

Conclusions and relevance

Community dwelling adults with CKD have elevated concentrations of cardiac biomarkers, above established reference ranges. Of the troponin assays, hs-cTnI concentration appears to be most stable across eGFR categories and is associated with CVD mortality.

SUBMITTER: Claudel SE

PROVIDER: S-EPMC10760296 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Publications

Association of cardiac biomarkers, kidney function, and mortality among adults with chronic kidney disease.

Claudel Sophie E SE Waikar Sushrut S SS Gopal Deepa M DM Verma Ashish A

medRxiv : the preprint server for health sciences 20231214

<h4>Background and aims</h4>The performance of high sensitivity troponin T (hs-cTnT), hs-cTnI, and N-terminal pro-hormone brain natriuretic peptide (NT-proBNP) in patients with chronic kidney disease (CKD) is poorly understood.<h4>Methods</h4>We included adults with CKD (eGFR<60 ml/min/1.73m<sup>2</sup>) in the 1999-2004 NHANES. We calculated the 99<sup>th</sup> percentile of hs-cTnT, hs-cTnI (Abbott, Ortho, and Siemens assays), and NT-proBNP, measured the association between eGFR and cardiac bi ...[more]

PMID: 38168327

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Dataset Information

Association of cardiac biomarkers, kidney function, and mortality among adults with chronic kidney disease.

Background and aims

Methods

Results

Conclusions and relevance

Publications

Association of cardiac biomarkers, kidney function, and mortality among adults with chronic kidney disease.

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