Exosomes secreted by ST3GAL5^high cancer cells promote peritoneal dissemination by establishing a premetastatic microenvironment.

ABSTRACT: Peritoneal dissemination of cancer affects patient survival. The behavior of peritoneal mesothelial cells (PMCs) and immune cells influences the establishment of a microenvironment that promotes cancer cell metastasis in the peritoneum. Here, we investigated the roles of lactosylceramide alpha-2,3-sialyltransferase (ST3G5; also known as ST3GAL5 and GM3 synthase) in the exosome-mediated premetastatic niche in peritoneal milky spots (MSs). Exosomes secreted from ST3G5^high cancer cells (ST3G5^high -cExos) were found to contain high levels of hypoxia-inducible factor 1-alpha (HIF1α) and accumulated in MSs via uptake in macrophages (MΦs) owing to increased expression of sialic acid-binding Ig-like lectin 1 (CD169; also known as SIGLEC1). ST3G5^high -cExos induced

SUBMITTER: Horie M 

PROVIDER: S-EPMC10766203 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature