Rifampin urinary excretion to predict serum targets in children with tuberculosis: a prospective diagnostic accuracy study.

ABSTRACT:

Objective

Pharmacokinetic variability drives tuberculosis (TB) treatment outcomes but measurement of serum drug concentrations for personalised dosing is inaccessible for children in TB-endemic settings. We compared rifampin urine excretion for prediction of a serum target associated with treatment outcome.

Design

Prospective diagnostic accuracy study.

Setting

Inpatient wards and outpatient clinics, northern Tanzania.

Patients

Children aged 4-17 years were consecutively recruited on initiation of WHO-approved treatment regimens.

Interventions

Samples were collected after directly observed therapy at least 2 weeks after initiation in the intensive phase: serum at pre-dose and 1, 2 and 6 hours post-dose, later analysed by liquid chromatography-tandem mass

SUBMITTER: Thomas TA 

PROVIDER: S-EPMC10766442 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature