Progress of non-small-cell lung cancer with ROS1 rearrangement.
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ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC10766828 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Publications
Progress of non-small-cell lung cancer with <i>ROS1</i> rearrangement.
Yang Xin X Tang Zhe Z Li Jing J Jiang Jizong J Liu Yue Y
Frontiers in molecular biosciences 20231222
<i>ROS1</i> rearrangement is found in 0.9%-2.6% of people with non-small-cell lung cancers (NSCLCs). Tyrosine kinase inhibitors (TKIs) target <i>ROS1</i> and can block tumor growth and provide clinical benefits to patients. This review summarizes the current knowledge on <i>ROS1</i> rearrangements in NSCLCs, including the mechanisms of <i>ROS1</i> oncogenicity, epidemiology of <i>ROS1</i>-positive tumors, methods for detecting rearrangements, molecular characteristics, therapeutic agents, and me ...[more]
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