Comparison of ROS1-rearrangement detection methods in a cohort of surgically resected non-small cell lung carcinomas.

ABSTRACT:

Background

Patients with non-small cell lung cancer (NSCLC) harboring a ROS proto-oncogene 1 (ROS1)-rearrangement respond to treatment with ROS1 inhibitors. To distinguish these rare cases, screening with immunohistochemistry (IHC) for ROS1 protein expression has been suggested. However, the reliability of such an assay and the comparability of the antibody clones has been debated. Therefore we evaluated the diagnostic performance of current detection strategies for ROS1-rearrangement in two NSCLC-patient cohorts.

Methods

Resected tissue samples, retrospectively collected from consecutive NSCLC-patients surgically treated at Uppsala University Hospital were incorporated into tissue microarrays [all n=676, adenocarcinomas (AC) n=401, squamous cell carcinomas (SCC) n=213, othe

SUBMITTER: Thurfjell V 

PROVIDER: S-EPMC9830269 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature