A Miniaturized, Battery-Free, Wireless Wound Monitor That Predicts Wound Closure Rate Early.

ABSTRACT: Diabetic foot ulcers are chronic wounds that affect millions and increase the risk of amputation and mortality, highlighting the critical need for their early detection. Recent demonstrations of wearable sensors enable real-time wound assessment, but they rely on bulky electronics, making them difficult to interface with wounds. Herein, a miniaturized, wireless, battery-free wound monitor that measures lactate in real-time and seamlessly integrates with bandages for conformal attachment to the wound bed is introduced. Lactate is selected due to its multifaceted role in initiating healing. Studies in healthy and diabetic mice reveal distinct lactate profiles for normal and impaired healing wounds. A mathematical model based on the sensor data predicts wound closure rate within the first 3 d

SUBMITTER: Garland NT 

PROVIDER: S-EPMC10766868 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature