High-grade glioma in infants and young children is histologically, molecularly, and clinically diverse: Results from the SJYC07 trial and institutional experience.

ABSTRACT:

Background

High-grade gliomas (HGG) in young children pose a challenge due to favorable but unpredictable outcomes. While retrospective studies broadened our understanding of tumor biology, prospective data is lacking.

Methods

A cohort of children with histologically diagnosed HGG from the SJYC07 trial was augmented with nonprotocol patients with HGG treated at St. Jude Children's Research Hospital from November 2007 to December 2020. DNA methylome profiling and whole genome, whole exome, and RNA sequencing were performed. These data were integrated with histopathology to yield an integrated diagnosis. Clinical characteristics and preoperative imaging were analyzed.

Results

Fifty-six children (0.0-4.4 years) were identified. Integrated analysis split the cohort into f

SUBMITTER: Chiang J 

PROVIDER: S-EPMC10768990 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature