Ontology highlight
ABSTRACT:
SUBMITTER: Lum GR
PROVIDER: S-EPMC10769314 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Lum Gregory R GR Ha Sung Min SM Olson Christine A CA Blencowe Montgomery M Paramo Jorge J Reyes Beck B Matsumoto Joyce H JH Yang Xia X Hsiao Elaine Y EY
Cell reports 20231208 12
The gut microbiome modulates seizure susceptibility and the anti-seizure effects of the ketogenic diet (KD) in animal models, but whether these relationships translate to KD therapies for human epilepsy is unclear. We find that the clinical KD alters gut microbial function in children with refractory epilepsy. Colonizing mice with KD-associated microbes promotes seizure resistance relative to matched pre-treatment controls. Select metagenomic and metabolomic features, including those related to ...[more]