Regulation of the transcription factor CdnL promotes adaptation to nutrient stress in Caulobacter.

ABSTRACT: In response to nutrient deprivation, bacteria activate a conserved stress response pathway called the stringent response (SR). During SR activation in Caulobacter crescentus, SpoT synthesizes the secondary messengers (p)ppGpp, which affect transcription by binding RNA polymerase to downregulate anabolic genes. (p)ppGpp also impacts expression of anabolic genes by controlling the levels and activities of their transcriptional regulators. In Caulobacter, a major regulator of anabolic genes is the transcription factor CdnL. If and how CdnL is controlled during the SR and why that might be functionally important is unclear. Here, we show that CdnL is downregulated post-translationally during starvation in a manner dependent on SpoT and the ClpXP protease. Inappropriate stabilizat

SUBMITTER: Smith EL 

PROVIDER: S-EPMC10769358 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature