Molecular Engineering of Self-Immolative Bioresponsive MR Probes.

ABSTRACT: Real-time detection of bio-event in whole animals provides essential information for understanding biological and therapeutic processes. Magnetic resonance (MR) imaging represents a non-invasive approach to generating three-dimensional anatomic images with high spatial-temporal resolution and unlimited depth penetration. We have developed several self-immolative enzyme-activatable agents that provide excellent in vivo contrast and function as gene expression reporters. Here, we describe a vast improvement in image contrast over our previous generations of these bioresponsive agents based on a new pyridyl-carbamate Gd(III) complex. The pyridyl-carbamate-based agent has a very low MR relaxivity in the "off-state" (r₁ = 1.8 mM^-1 s^-1 at 1.41 T). However,

SUBMITTER: Tang JH 

PROVIDER: S-EPMC10769484 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature