Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation.

ABSTRACT: The bone-derived hormone fibroblast growth factor-23 (FGF23) has recently received much attention due to its association with chronic kidney disease and cardiovascular disease progression. Extracellular sodium concentration ([Na⁺]) plays a significant role in bone metabolism. Hyponatremia (lower serum [Na⁺]) has recently been shown to be independently associated with FGF23 levels in patients with chronic systolic heart failure. However, nothing is known about the direct impact of [Na⁺] on FGF23 production. Here, we show that an elevated [Na⁺] (+20 mM) suppressed FGF23 formation, whereas low [Na⁺] (-20 mM) increased FGF23 synthesis in the osteoblast-like cell lines UMR-106 and MC3T3-E1. Similar bidirectional changes in FGF23 abundance w

SUBMITTER: Radvanyi Z 

PROVIDER: S-EPMC10770535 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature