Characterizing the metabolic divide: distinctive metabolites differentiating CAD-T2DM from CAD patients.

ABSTRACT:

Objective

To delineate the metabolomic differences in plasma samples between patients with coronary artery disease (CAD) and those with concomitant CAD and type 2 diabetes mellitus (T2DM), and to pinpoint distinctive metabolites indicative of T2DM risk.

Method

Plasma samples from CAD and CAD-T2DM patients across three centers underwent comprehensive metabolomic and lipidomic analyses. Multivariate logistic regression was employed to discern the relationship between the identified metabolites and T2DM risk. Characteristic metabolites' metabolic impacts were further probed through hepatocyte cellular experiments. Subsequent transcriptomic analyses elucidated the potential target sites explaining the metabolic actions of these metabolites.

Results

Metabolomic analysis re

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10771670 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature