A narrative review of the evolving landscape of the management of metastatic gastric cancer: the role of targeted therapies.

ABSTRACT:

Background and objective

Gastric cancer is the fifth most common cancer worldwide and the fourth leading cause of cancer-related death. Unfortunately, patients often present with advanced disease at diagnosis, which is directly related to its high mortality. Numerous trials, as early as the 1980's, have shown that cytotoxic chemotherapy improves survival. This review will focus on targeted therapies and immunotherapies which have emerged as treatment options for metastatic gastric cancer, often used in conjunction with cytotoxic chemotherapy. Here we will review the relevant clinical trials of targeted therapies and immunotherapies in the treatment of metastatic gastric cancer.

Methods

We performed an extensive review of articles in the PubMed database pertaining to targeted

SUBMITTER: Delgado-Ramos GM 

PROVIDER: S-EPMC10772679 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature