The role of genetic factors in pediatric myelodysplastic syndromes with different outcomes.

ABSTRACT:

Background

Pediatric myelodysplastic syndromes (MDS) are rare disorders with an unrevealed pathogenesis. Our aim is to explore the role of genetic factors in the pathogenesis of MDS in children with different outcomes and to discover the correlation between genetic features and clinical outcomes as well as disease characteristics.

Methods

We conducted an analysis of archived genetic data from 26 patients diagnosed with pediatric MDS at our institution between 2015 and 2021, examining the association between different genetic characteristics and clinical manifestations as well as prognosis. Additionally, We presented three cases with distinct genetic background and outcomes as examples to elaborate the role of genetic factors in pediatric MDS with different prognoses.

Resu

SUBMITTER: Li Y 

PROVIDER: S-EPMC10773107 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature