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Oxidative stress in myelodysplastic syndromes

ABSTRACT: Control of oxidative stress in the bone marrow (BM) is key for maintaining the balance between self-renewal, proliferation, and differentiation of hematopoietic cells. Breakdown of this regulation can lead to diseases characterized by BM failure such as the myelodysplastic syndromes (MDS). To better understand the role of oxidative stress in MDS development, we compared protein carbonylation as an oxidative stress marker in BM of patients with MDS and control subjects, and also patients with MDS under treatment with the iron chelator deferasirox.

INSTRUMENT(S): 4800 Plus MALDI TOF/TOF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Bone Marrow

DISEASE(S): Myelodysplastic Syndrome

SUBMITTER: Alba Rodriguez

LAB HEAD: Joaquín Martínez

PROVIDER: PXD013609 | Pride | 2019-10-30

REPOSITORIES: Pride

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Protein Carbonylation in Patients with Myelodysplastic Syndrome: An Opportunity for Deferasirox Therapy.

Rodríguez-García Alba A Morales María Luz ML Garrido-García Vanesa V García-Baquero Irene I Leivas Alejandra A Carreño-Tarragona Gonzalo G Sánchez Ricardo R Arenas Alicia A Cedena Teresa T Ayala Rosa María RM Bautista José M JM Martínez-López Joaquín J Linares María M

Antioxidants (Basel, Switzerland) 20191024 11

Control of oxidative stress in the bone marrow (BM) is key for maintaining the interplay between self-renewal, proliferation, and differentiation of hematopoietic cells. Breakdown of this regulation can lead to diseases characterized by BM failure such as the myelodysplastic syndromes (MDS). To better understand the role of oxidative stress in MDS development, we compared protein carbonylation as an indicator of oxidative stress in the BM of patients with MDS and control subjects, and also patie ...[more]

PMID: 31652983

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