TAK1 Activation by NLRP3 Deficiency Confers Cardioprotection Against Pressure Overload-Induced Cardiomyocyte Pyroptosis and Hypertrophy.
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SUBMITTER: Li X
PROVIDER: S-EPMC10774584 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
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TAK1 Activation by NLRP3 Deficiency Confers Cardioprotection Against Pressure Overload-Induced Cardiomyocyte Pyroptosis and Hypertrophy.
Li Xuan X You Jieyun J Dai Fangjie F Wang Shijun S Yang Feng Hua FH Wang Xingxu X Ding Zhiwen Z Huang Jiayuan J Chen Liming L Abudureyimu Miyesaier M Tang Haiyang H Yang Xiangdong X Xiang Yaozu Y Backx Peter H PH Ren Jun J Ge Junbo J Zou Yunzeng Y Wu Jian J
JACC. Basic to translational science 20230809 12
A comprehensive view of the role of NLRP3/caspase-1/GSDMD-mediated pyroptosis in pressure overload cardiac hypertrophy is presented in this study. Furthermore, mitigation of NLRP3 deficiency-induced pyroptosis confers cardioprotection against pressure overload through activation of TAK1, whereas this salutary effect is abolished by inhibition of TAK1 activity, highlighting a previously unrecognized reciprocally regulatory role of NLRP3-TAK1 governing inflammation-induced cell death and hypertrop ...[more]
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