Natural killer cells drive 4-1BBL positive uveal melanoma towards EMT and metastatic disease.

ABSTRACT:

Background

Inflammation in the eye is often associated with aggravated ocular diseases such as uveal melanoma (UM). Poor prognosis of UM is generally associated with high potential of metastatic liver dissemination. A strong driver of metastatic dissemination is the activation of the epithelial-mesenchymal transition (EMT) regulating transcription factor ZEB1, and high expression of ZEB1 is associated with aggressiveness of UM. While ZEB1 expression can be also associated with immune tolerance, the underlying drivers of ZEB1 activation remain unclear.

Methods

Transcriptomic, in vitro, ex vivo, and in vivo analyses were used to investigate the impact on clinical prognosis of immune infiltration in the ocular tumor microenvironment. A metastatic liver dissemination model of wa

SUBMITTER: Neo SY 

PROVIDER: S-EPMC10775428 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature