Liver shape analysis using statistical parametric maps at population scale.

ABSTRACT:

Background

Morphometric image analysis enables the quantification of differences in the shape and size of organs between individuals.

Methods

Here we have applied morphometric methods to the study of the liver by constructing surface meshes from liver segmentations from abdominal MRI images in 33,434 participants in the UK Biobank. Based on these three dimensional mesh vertices, we evaluated local shape variations and modelled their association with anthropometric, phenotypic and clinical conditions, including liver disease and type-2 diabetes.

Results

We found that age, body mass index, hepatic fat and iron content, as well as, health traits were significantly associated with regional liver shape and size. Interaction models in groups with specific clinical condition

SUBMITTER: Thanaj M 

PROVIDER: S-EPMC10775563 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature