Effect of Risk Mitigation Guidance opioid and stimulant dispensations on mortality and acute care visits during dual public health emergencies: retrospective cohort study.

ABSTRACT:

Objective

To determine the effect of opioid and stimulant Risk Mitigation Guidance (RMG) dispensations on mortality and acute care visits during the dual public health emergencies of overdose and covid-19.

Design

Population based retrospective cohort study.

Setting

British Columbia, Canada.

Participants

5882 people with opioid or stimulant use disorder who received RMG prescriptions for opioids (n=5356) and/or stimulants (n=1061) (535 received both) from 27 March 2020 to 31 August 2021.

Main outcome measures

All cause and overdose specific mortality and acute care visits in the week after RMG opioid or stimulant dispensation. RMG recipients were matched 1:1 with controls through use of high dimensional propensity score matching. Marginal structural model

SUBMITTER: Slaunwhite A 

PROVIDER: S-EPMC10777271 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature