Phenotypic and metabolomic characteristics of mouse models of metabolic associated steatohepatitis.

ABSTRACT:

Background

Metabolic associated steatohepatitis (MASH) is metabolic disease that may progress to cirrhosis and hepatocellular carcinoma. Mouse models of diet-induced MASH, which is characterized by the high levels of fats, sugars, and cholesterol in diets, are commonly used in research. However, mouse models accurately reflecting the progression of MASH in humans remain to be established. Studies have explored the potential use of serological metabolites as biomarkers of MASH severity in relation to human MASH.

Methods

We performed a comparative analysis of three mouse models of diet-induced MASH in terms of phenotypic and metabolomic characteristics; MASH was induced using different diets: a high-fat diet; a Western diet; and a high-fat, high-cholesterol diet. Liver cirrhos

SUBMITTER: Yang CR 

PROVIDER: S-EPMC10777576 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature