Platelet microRNAs as Potential Novel Biomarkers for Antiplatelet Therapy with P2Y₁₂ Inhibitors and Their Association with Platelet Function.

ABSTRACT:

Introduction

Patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) require dual antiplatelet therapy (DAPT). However, the response to treatment can vary considerably. Certain platelet microRNAs (miRs) are suspected to predict DAPT response and influence platelet function. This study aimed to analyze selected miRs' expressions and compare them among patients treated with different P2Y₁₂ inhibitors while assessing their association with platelet activity and turnover parameters.

Materials and methods

We recruited 79 ACS patients post-PCI treated with clopidogrel, ticagrelor, or prasugrel, along with 18 healthy volunteers. Expression levels of miR-126-3p, miR223-3p, miR-21-5p, miR-197-3p, and miR-24-3p, as well as immature pl

SUBMITTER: Gumiezna K 

PROVIDER: S-EPMC10780110 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature