Observational and genetic associations between cardiorespiratory fitness and cancer: a UK Biobank and international consortia study.

ABSTRACT:

Background

The association of fitness with cancer risk is not clear.

Methods

We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of lung, colorectal, endometrial, breast, and prostate cancer in a subset of UK Biobank participants who completed a submaximal fitness test in 2009-12 (N = 72,572). We also investigated relationships using two-sample Mendelian randomisation (MR), odds ratios (ORs) were estimated using the inverse-variance weighted method.

Results

After a median of 11 years of follow-up, 4290 cancers of interest were diagnosed. A 3.5 ml O₂⋅min^-1⋅kg^-1 total-body mass increase in fitness (equivalent to 1 metabolic equivalent of task (MET), approximately 0.5 standar

SUBMITTER: Watts EL 

PROVIDER: S-EPMC10781786 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature