Prediction of immune infiltration and prognosis for patients with gastric cancer based on the immune-related genes signature.

ABSTRACT:

Objective

The immune microenvironment influenced clinical outcomes and treatment response of gastric cancer (GC) patients. Though thousands of immune-related genes (IRGs) have been identified, their effects on GC are not fully understood. The objective of the study is to analyze the correlations between the expression and effect of IRGs and clinical outcomes. Moreover, we evaluate the efficacy and value of utilizing the immune-related genes signature as a prognosis prediction model for GC patients.

Methods

We identified the differentially expressed IRGs and systematically analyzed their functions. We constructed a novel GC prognostic signature and a new nomogram, Moreover, we explored the infiltrated immune cell types in the immune microenvironment and discussed the genetic

SUBMITTER: Li X 

PROVIDER: S-EPMC10782158 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature