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Pharmacokinetics and safety evaluation of intravenously administered Pseudomonas phage PA_LZ7 in a mouse model.

ABSTRACT:

Importance

Phage therapy is gaining traction as an alternative to antibiotics due to the rise of multi-drug-resistant (MDR) bacteria. This study assessed the pharmacokinetics and safety of PA_LZ7, a phage targeting MDR Pseudomonas aeruginosa, in mice. After intravenous administration, the phage showed an exponential decay in plasma and its concentration dropped significantly within 24 h for all dosage groups. Although there was a temporary increase in certain plasma cytokines and spleen weight at higher dosages, no significant toxicity was observed. Therefore, PA_LZ7 shows potential as an effective and safe candidate for future phage therapy against MDR P. aeruginosa infections.

SUBMITTER: Wang S-y

PROVIDER: S-EPMC10783130 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Pharmacokinetics and safety evaluation of intravenously administered <i>Pseudomonas</i> phage PA_LZ7 in a mouse model.

Wang Si-Yun S-y Tan Xin X Liu Zi-Qiang Z-q Ma Hui H Liu Tian-Bin T-b Yang Yong-Qing Y-q Ying Yong Y Gao Ru-Yue R-y Zhang Dai-Zhou D-z Ma Ying-Fei Y-f Chen Kai K Lin Lin L Jiang Zhi-Huan Z-h Yu Jia-Lin J-l

Microbiology spectrum 20231128 1

<h4>Importance</h4>Phage therapy is gaining traction as an alternative to antibiotics due to the rise of multi-drug-resistant (MDR) bacteria. This study assessed the pharmacokinetics and safety of PA_LZ7, a phage targeting MDR <i>Pseudomonas aeruginosa</i>, in mice. After intravenous administration, the phage showed an exponential decay in plasma and its concentration dropped significantly within 24 h for all dosage groups. Although there was a temporary increase in certain plasma cytokines and ...[more]

PMID: 38014983

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