The Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal Compared With Conventional Lung Protective Ventilation on Cardiac Function.

ABSTRACT:

Objectives

Lower tidal volume ventilation (targeting 3 mL/kg predicted body weight, PBW) facilitated by extracorporeal carbon dioxide removal (ECCO₂R) has been investigated as a potential therapy for acute hypoxemic respiratory failure (AHRF) in the pRotective vEntilation with veno-venouS lung assisT in respiratory failure (REST) trial. We investigated the effect of this strategy on cardiac function, and in particular the right ventricle.

Design

Substudy of the REST trial.

Setting

Nine U.K. ICUs.

Patients

Patients with AHRF (Pao₂/Fio₂ < 150 mm Hg [20 kPa]).

Intervention

Transthoracic echocardiography and N-terminal pro-B-type natriuretic peptide (NT-proBNP) measurements were collected at baseline and postrandomization in

SUBMITTER: McGuigan PJ 

PROVIDER: S-EPMC10783412 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature