Clinical and Laboratory Correlates of QTc Duration in Adult and Pediatric Sickle Cell Disease.

ABSTRACT:

Background

Sickle cell disease, a common genetic disorder in African Americans, manifests an increased risk of sudden death, the basis of which is incompletely understood. Prolongation of heart rate-corrected QT (QTc) interval on the electrocardiogram, a standard clinical measure of cardiac repolarization, may contribute to sudden death by predisposing to torsades de pointes ventricular tachycardia.

Methods

We established a cohort study of 293 adult and 121 pediatric sickle cell disease patients drawn from the same geographic region as the Jackson Heart Study (JHS) cohort, in which significant correlates of QT duration have been characterized and quantitatively modeled. Herein, we establish clinical and laboratory correlates of QTc duration in our cohort using stepwis

SUBMITTER: Yu X 

PROVIDER: S-EPMC10785202 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature