Age-related decline in melatonin contributes to enhanced osteoclastogenesis via disruption of redox homeostasis.

ABSTRACT:

Background

Increased oxidative stress contributes to enhanced osteoclastogenesis and age-related bone loss. Melatonin (MT) is an endogenous antioxidant and declines with aging. However, it was unclear whether the decline of MT was involved in the enhanced osteoclastogenesis during the aging process.

Methods

The plasma level of MT, oxidative stress status, bone mass, the number of bone marrow-derived monocytes (BMMs) and its osteoclastogenesis were analyzed in young (3-month old) and old (18-month old) mice (n = 6 per group). In vitro, BMMs isolated from aged mice were treated with or without MT, followed by detecting the change of osteoclastogenesis and intracellular reactive oxygen species (ROS) level. Furthermore, old mice were treated with MT for 2 months to investigate t

SUBMITTER: Wu DZ 

PROVIDER: S-EPMC10785421 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature