Stereo-EEG-guided network modulation for psychiatric disorders: Surgical considerations.

ABSTRACT:

Background

Deep brain stimulation (DBS) and other neuromodulatory techniques are being increasingly utilized to treat refractory neurologic and psychiatric disorders.

Objective

/Hypothesis: To better understand the circuit-level pathophysiology of treatment-resistant depression (TRD) and treat the network-level dysfunction inherent to this challenging disorder, we adopted an approach of inpatient intracranial monitoring borrowed from the epilepsy surgery field.

Methods

We implanted 3 patients with 4 DBS leads (bilateral pair in both the ventral capsule/ventral striatum and subcallosal cingulate) and 10 stereo-electroencephalography (sEEG) electrodes targeting depression-relevant network regions. For surgical planning, we used an interactive, holographic visualization

SUBMITTER: Sheth SA 

PROVIDER: S-EPMC10787578 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature