Histologic features and predicting prognosis in ulcerative colitis patients with mild endoscopic activity.

ABSTRACT:

Background/aims

We aimed to evaluate the histologic features predictive of prognosis and correlate them with endoscopic findings in patients with ulcerative colitis (UC) having complete or partial mucosal healing (MH).

Methods

We prospectively collected and reviewed data from patients with UC who underwent colonoscopy or sigmoidoscopy with biopsy. Complete and partial MH were defined as Mayo endoscopic subscores (MESs) of 0 and 1, respectively. Histologic variables, including the Nancy index (NI), predicting disease progression (defined as the need for medication upgrade or hospitalization/surgery), were evaluated and correlated with endoscopic findings.

Results

Overall, 441 biopsy specimens were collected from 194 patients. The average follow-up duration was 14.7 ± 7

SUBMITTER: Shin SY 

PROVIDER: S-EPMC10790054 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature