From intestine to beyond: Salmonella entry factors display distinct transcription pattern upon infection in murine models.

ABSTRACT: The infectious process of bacteria of the genus Salmonella requires the finely regulated use of various virulence factors. Among them, the type 3 secretion system-1 (T3SS-1) and the Rck and PagN invasins are involved in the internalization of the pathogen within eukaryotic cells, but their precise role in the host and in the pathogenic process is still poorly understood. In this study, we aimed to determine the kinetics of expression of these entry factors in a typhoid fever-like and a gastroenteritis model in mice by in vivo imaging using bioluminescent Salmonella Typhimurium reporter strains carrying chromosomal transcriptional fusions. Only pagN and T3SS-1 transcription has been clearly identified. Independently of the pathological model, the caecum was ident

SUBMITTER: Koczerka M 

PROVIDER: S-EPMC10791514 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature