Real-world use of Safinamide in motor fluctuating Parkinson's disease patients in Italy.

ABSTRACT:

Introduction

Safinamide is a recent antiparkinsonian drug that modulates both dopaminergic and glutamatergic systems with positive effects on motor and nonmotor symptoms of Parkinson's disease (PD). Here, we aimed to describe the efficacy and safety of safinamide in the Italian PD patients in real-life conditions.

Methods

We performed a sub-analysis of the Italian cohort of the SYNAPSES study, a multi-country, multi-center, retrospective-prospective cohort observational study, designed to investigate the use of safinamide in routine clinical practice. Patients received for the first time a treatment with safinamide and were followed up for 12 months. The analysis was conducted on the overall population and in subgroups of interest: i) patients > 75 years, ii) patients with r

SUBMITTER: Bovenzi R 

PROVIDER: S-EPMC10791801 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature