Integrative network analysis suggests prioritised drugs for atopic dermatitis.

ABSTRACT:

Background

Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease whose pathophysiology involves the interplay between genetic and environmental factors, ultimately leading to dysfunction of the epidermis. While several treatments are effective in symptom management, many existing therapies offer only temporary relief and often come with side effects. For this reason, the formulation of an effective therapeutic plan is challenging and there is a need for more effective and targeted treatments that address the root causes of the condition. Here, we hypothesise that modelling the complexity of the molecular buildup of the atopic dermatitis can be a concrete means to drive drug discovery.

Methods

We preprocessed, harmonised and integrated publicly available tra

SUBMITTER: Federico A 

PROVIDER: S-EPMC10792836 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature