Serum Levels of Vitamin C and Thiamin in Children With Suspected Sepsis: A Prospective Observational Cohort Study.

ABSTRACT:

Objectives

Vitamin C and thiamin have been trialed as adjunctive therapies in adults with septic shock but their role in critically ill children is unclear. We assessed serum levels of vitamin C and thiamin in children evaluated for sepsis.

Design

Single-center prospective observational study. Serum levels of vitamin C and thiamin were measured on admission and association with multiple organ dysfunction syndrome (MODS) was explored using logistic regression.

Setting

Emergency department and PICU in a tertiary children's hospital, Queensland, Australia.

Patients

Children greater than 1 month and less than 17 years evaluated for sepsis.

Interventions

Not applicable.

Measurements and main results

Vitamin levels were determined in 221 children with a

SUBMITTER: McWhinney B 

PROVIDER: S-EPMC10793743 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature