Exploring the intestinal ecosystem: from gut microbiota to associations with subtypes of inflammatory bowel disease.

ABSTRACT:

Objective

Significant differences have been discovered between subtypes of Crohn's disease (CD) and ulcerative colitis (UC). The role of gut microbiota in promoting the onset of UC and CD is established, but conclusions regarding subtype-specific analyses remain limited.

Methods

This study aims to explore the influence of gut microbiota on subtypes of UC and CD, offering novel insights into the pathogenesis and treatment of UC and CD.Two-sample Mendelian randomization (MR) analysis was employed to examine the causal relationship between subtypes of UC and CD and gut microbiota composition. Gut microbiota data were sourced from the International Consortium MiBioGen, while UC and CD data were obtained from FINNGEN. Eligible single nucleotide polymorphisms (SNPs) were selected

SUBMITTER: Li F 

PROVIDER: S-EPMC10794348 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature