Update of the risk assessment of inorganic arsenic in food.

ABSTRACT: The European Commission asked EFSA to update its 2009 risk assessment on arsenic in food carrying out a hazard assessment of inorganic arsenic (iAs) and using the revised exposure assessment issued by EFSA in 2021. Epidemiological studies show that the chronic intake of iAs via diet and/or drinking water is associated with increased risk of several adverse outcomes including cancers of the skin, bladder and lung. The CONTAM Panel used the benchmark dose lower confidence limit based on a benchmark response (BMR) of 5% (relative increase of the background incidence after adjustment for confounders, BMDL₀₅) of 0.06 μg iAs/kg bw per day obtained from a study on skin cancer as a Reference Point (RP). Inorganic As is a genotoxic carcinogen with additional epigenetic effects and the CO

SUBMITTER: EFSA Panel on Contaminants in the Food Chain (CONTAM) 

PROVIDER: S-EPMC10794945 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature