Histological Phenotyping in Eosinophilic Esophagitis: Localized Proximal Disease Is Infrequent but Associated with Less Severe Disease and Better Disease Outcome.

ABSTRACT:

Introduction

It is still unknown whether eosinophilic esophagitis (EoE) patients with localized disease are different from those with extended disease.

Methods

We evaluated prospectively included patients in the Swiss EoE cohort. Data on all patients with active disease at baseline, no concomitant gastroesophageal reflux disease, no strictures at baseline, and at least one follow-up visit were analyzed. We compared patients with histologically localized proximal versus distal versus extended (=proximal and distal) disease with regard to patient, disease characteristics, disease presentation, and development of complications.

Results

We included 124 patients with a median of 2.5 years of follow-up (73.4% males, median age 35.0 years). Ten patients had proximal (8.1%),

SUBMITTER: Heil A 

PROVIDER: S-EPMC10794962 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature