Longitudinal patterns of inflammatory mediators after acute HIV infection correlate to intact and total reservoir.

ABSTRACT:

Background

Despite the beneficial effects of antiretroviral therapy (ART) initiation during acute HIV infection (AHI), residual immune activation remains a hallmark of treated HIV infection.

Methods

Plasma concentrations of 40 mediators were measured longitudinally in 39 early treated participants of a Belgian AHI cohort (HIV+) and in 21 HIV-negative controls (HIV-). We investigated the association of the inflammatory profile with clinical presentation, plasma viral load, immunological parameters, and in-depth characterization of the HIV reservoir.

Results

While levels of most soluble mediators normalized with suppressive ART, we demonstrated the persistence of a pro-inflammatory signature in early treated HIV+ participants in comparison to HIV- controls. Examination

SUBMITTER: De Clercq J 

PROVIDER: S-EPMC10796502 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature