Ravidomycin Analogs from Streptomyces sp. Exhibit Altered Antimicrobial and Cytotoxic Selectivity.

ABSTRACT: Six new ravidomycin analogs (1-4, 6, and 7) were isolated from Streptomyces sp. Am59 using UV- and LCMS-guided separation based on Global Natural Products Social (GNPS) molecular networking analysis. Furthermore, we isolated fucomycin V (9), which possesses the same chromophore as ravidomycin but features a d-fucopyranose instead of d-ravidosamine. This is the first report of 9 as a natural product. Four new analogs (10-13) of 9 were also isolated. The structures were elucidated by combined spectroscopic and computational methods. We also found an inconsistency with the published [α]_D²⁵ of deacetylravidomycin, which is reported to have a (-) sign. Instead, we observed a (+) specific rotation for the

SUBMITTER: Park KJ 

PROVIDER: S-EPMC10797603 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature