Long-term safety of dietary salt: A 5-year ProspEctive rAndomized bliNded and controlled stUdy in healThy aged cats (PEANUT study).

ABSTRACT:

Background

High-salt diets promote urine dilution and decrease urolithiasis risk.

Objective

Prospectively evaluate the safety of chronic high dietary salt intake (randomized controlled trial).

Animals

Twenty research colony neutered, healthy aged cats (11.5 years [10.0-11.6], median [interquartile range]).

Methods

Healthy cats were randomized to control or high-salt dry diets (sodium: 1.02 ± 0.16 [mean, SD] and 3.26 ± 0.30 g/Mcal metabolizable energy [ME], respectively; chloride: 2.26 ± 0.33 and 5.71 ± 0.28 g/Mcal ME, respectively), fed for up to 60 months. Assessments included CBC, plasma biochemistry, urinalysis, glomerular filtration rate (GFR), blood pressure, renal and cardiac (conventional Doppler and 2-dimensional color tissue Doppler) imaging, annually.

SUBMITTER: Reynolds BS 

PROVIDER: S-EPMC10800216 | biostudies-literature | 2024 Jan-Feb

REPOSITORIES: biostudies-literature