Comprehensive analysis of senescence-associated genes in sepsis based on bulk and single-cell sequencing data.

ABSTRACT: Background: Sepsis is a pathological state resulting from dysregulated immune response in host during severe infection, leading to persistent organ dysfunction and ultimately death. Senescence-associated genes (SAGs) have manifested their potential in controlling the proliferation and dissemination of a variety of diseases. Nevertheless, the correlation between sepsis and SAGs remains obscure and requires further investigation. Methods: Two RNA expression datasets (GSE28750 and GSE57065) specifically related to sepsis were employed to filter hub SAGs, based on which a diagnostic model predictive of the incidence of sepsis was developed. The association between the expression of the SAGs identified and immune-related modules was analyzed employing Cell-type Identification By E

SUBMITTER: Tao L 

PROVIDER: S-EPMC10801732 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature