Discovering genetic mechanisms underlying the co-occurrence of Parkinson's disease and non-motor traits.

ABSTRACT: Understanding the biological mechanisms that underlie the non-motor symptoms of Parkinson's disease (PD) requires comprehensive frameworks that unravel the complex interplay of genetic risk factors. Here, we used a disease-agnostic brain cortex gene regulatory network integrated with Mendelian Randomization analyses that identified 19 genes whose changes in expression were causally linked to PD. We further used the network to identify genes that are regulated by PD-associated genome-wide association study (GWAS) SNPs. Extended protein interaction networks derived from PD-risk genes and PD-associated SNPs identified convergent impacts on biological pathways and phenotypes, connecting PD with established co-occurring traits, including non-motor symptoms. These findings hold promise for thera

SUBMITTER: Gokuladhas S 

PROVIDER: S-EPMC10805842 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature