High-Density Lipoproteins at the Interface between the NLRP3 Inflammasome and Myocardial Infarction.

ABSTRACT: Despite significant therapeutic advancements, morbidity and mortality following myocardial infarction (MI) remain unacceptably high. This clinical challenge is primarily attributed to two significant factors: delayed reperfusion and the myocardial injury resulting from coronary reperfusion. Following reperfusion, there is a rapid intracellular pH shift, disruption of ionic balance, heightened oxidative stress, increased activity of proteolytic enzymes, initiation of inflammatory responses, and activation of several cell death pathways, encompassing apoptosis, necroptosis, and pyroptosis. The inflammatory cell death or pyroptosis encompasses the activation of the intracellular multiprotein complex known as the NLRP3 inflammasome. High-density lipoproteins (HDL) are endogenous particles whos

SUBMITTER: Carmo HRP 

PROVIDER: S-EPMC10816227 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature