Ontology highlight
ABSTRACT:
SUBMITTER: Xie D
PROVIDER: S-EPMC10816276 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Xie Dong D Fu Wengan W Yuan Tiantian T Han Kangjia K Lv Yuxiu Y Wang Qi Q Jiang Qian Q Zhang Yingjun Y Zhu Guolei G Xu Junming J Zhao Ping P Yang Xiaoqin X
International journal of molecular sciences 20240112 2
Tyrosinase is vital in fruit and vegetable browning and melanin synthesis, crucial for food preservation and pharmaceuticals. We investigated 6'-<i>O</i>-caffeoylarbutin's inhibition, safety, and preservation on tyrosinase. Using HPLC, we analyzed its effect on mushroom tyrosinase and confirmed reversible competitive inhibition. UV_vis and fluorescence spectroscopy revealed a stable complex formation with specific binding, causing enzyme conformational changes. Molecular docking and simulations ...[more]