Dataset Information

Prognostic Value of Radiomic Analysis Using Pre- and Post-Treatment ¹⁸F-FDG-PET/CT in Patients with Laryngeal Cancer and Hypopharyngeal Cancer.

ABSTRACT:

Background

The prognostic value of conducting ¹⁸F-FDG PET/CT imaging has yielded different results in patients with laryngeal cancer and hypopharyngeal cancer, but these results are controversial, and there is a lack of dedicated studies on each type of cancer. This study aimed to evaluate whether combining radiomic analysis of pre- and post-treatment ¹⁸F-FDG PET/CT imaging features and clinical parameters has additional prognostic value in patients with laryngeal cancer and hypopharyngeal cancer.

Methods

From 2008 to 2016, data on patients diagnosed with cancer of the larynx and hypopharynx were retrospectively collected. The patients underwent pre- and post-treatment ¹⁸F-FDG PET/CT imaging. The values of ΔPre-Post PET were measured from the texture features. Least absolute shrinkage and selection operator (LASSO) Cox regression was used to select the most predictive features to formulate a Rad-score for both progression-free survival (PFS) and overall survival (OS). Kaplan-Meier curve analysis and Cox regression were employed to assess PFS and OS. Then, the concordance index (C-index) and calibration plot were used to evaluate the performance of the radiomics nomogram.

Results

Study data were collected for a total of 91 patients. The mean follow-up period was 71.5 mo. (8.4-147.3). The Rad-score was formulated based on the texture parameters and was significantly associated with both PFS (p = 0.024) and OS (p = 0.009). When predicting PFS, only the Rad-score demonstrated a significant association (HR 2.1509, 95% CI [1.100-4.207], p = 0.025). On the other hand, age (HR 1.116, 95% CI [1.041-1.197], p = 0.002) and Rad-score (HR 33.885, 95% CI [2.891-397.175], p = 0.005) exhibited associations with OS. The Rad-score value showed good discrimination when it was combined with clinical parameters in both PFS (C-index 0.802-0.889) and OS (C-index 0.860-0.958). The calibration plots also showed a good agreement between the observed and predicted survival probabilities.

Conclusions

Combining clinical parameters with radiomics analysis of pre- and post-treatment ¹⁸F-FDG PET/CT parameters in patients with laryngeal cancer and hypopharyngeal cancer might have additional prognostic value.

SUBMITTER: Choi JH

PROVIDER: S-EPMC10817325 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Publications

Prognostic Value of Radiomic Analysis Using Pre- and Post-Treatment <sup>18</sup>F-FDG-PET/CT in Patients with Laryngeal Cancer and Hypopharyngeal Cancer.

Choi Joon Ho JH Choi Joon Young JY Woo Sang-Keun SK Moon Ji Eun JE Lim Chae Hong CH Park Soo Bin SB Seo Seongho S Ahn Yong Chan YC Ahn Myung-Ju MJ Moon Seung Hwan SH Park Jung Mi JM

Journal of personalized medicine 20240105 1

<h4>Background</h4>The prognostic value of conducting <sup>18</sup>F-FDG PET/CT imaging has yielded different results in patients with laryngeal cancer and hypopharyngeal cancer, but these results are controversial, and there is a lack of dedicated studies on each type of cancer. This study aimed to evaluate whether combining radiomic analysis of pre- and post-treatment <sup>18</sup>F-FDG PET/CT imaging features and clinical parameters has additional prognostic value in patients with laryngeal c ...[more]

PMID: 38248772

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Dataset Information

Prognostic Value of Radiomic Analysis Using Pre- and Post-Treatment ¹⁸F-FDG-PET/CT in Patients with Laryngeal Cancer and Hypopharyngeal Cancer.

Background

Methods

Results

Conclusions

Publications

Prognostic Value of Radiomic Analysis Using Pre- and Post-Treatment <sup>18</sup>F-FDG-PET/CT in Patients with Laryngeal Cancer and Hypopharyngeal Cancer.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Prognostic Value of Radiomic Analysis Using Pre- and Post-Treatment 18F-FDG-PET/CT in Patients with Laryngeal Cancer and Hypopharyngeal Cancer.

Background

Methods

Results

Conclusions

Publications

Prognostic Value of Radiomic Analysis Using Pre- and Post-Treatment <sup>18</sup>F-FDG-PET/CT in Patients with Laryngeal Cancer and Hypopharyngeal Cancer.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Prognostic Value of Radiomic Analysis Using Pre- and Post-Treatment ¹⁸F-FDG-PET/CT in Patients with Laryngeal Cancer and Hypopharyngeal Cancer.