TBC1D1 represses glioma progression by altering the integrity of the cytoskeleton.

ABSTRACT:

Background

Glioma is one of the most aggressive malignant brain tumors and is characterized by invasive growth and poor prognosis. TBC1D1, a member of the TBC family, is associated with the development of various malignancies. However, the role of TBC1D1 in glioma-genesis remains unclear.

Methods

The effect of TBC1D1 on the prognosis of glioma patients and related influencing factors were analyzed in the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) databases. Expression of TBC1D1 in glioma cell lines was detected by western blotting. Cell viability and proliferation were measured by EdU and Colony formation assays, respectively. Transwell and wound healing assays were performed to determine the cell migration and invasion capacities. Immunofluorescen

SUBMITTER: Cai J 

PROVIDER: S-EPMC10817367 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature